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  • Effects of OxyContin Abuse Abusing OxyContin can lead to various negative consequences to physical health. Snorting or smoking the substance causes the whole dosage contained within the time-release tablet to be released simultaneously, which can increase the risk of overdose.
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  • Long-Term Effects of Oxycodone. If used and abused for an extended period of time, Oxycodone can lead to grim long-term effects on both the brain and the body. Such feelings include: A Tolerance to Oxycodone. As mentioned, if you use oxycodone regularly, your body will adapt to its effects …
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